Alkaloid comparison matrix
Every compound that matters in this category, side by side: source plant, alkaloid family, federal status, whether state kratom acts reach it, and what job it does in a formula. Filter it however is useful.
Reviewed August 2026 by the Corydalis Labs Technical Team. How we research and review.
11 compounds shown
| Compound | Source | Family | Status | Federal position | Kratom acts apply? | Role in a formula |
|---|---|---|---|---|---|---|
| 13-OH Corydalis Yanhusuo 13-OH | Corydalis yanhusuo | Isoquinoline | Clear | Not scheduled | No | Synergist — 25–40 mg per serving |
| Tetrahydropalmatine THP, l-THP, rotundine | Corydalis yanhusuo | Isoquinoline | Clear | Not scheduled | No | Parent alkaloid; less contribution per mg |
| Mitragynine MIT | Mitragyna speciosa | Indole | Regulated | Not federally scheduled | Yes — full scope | Primary active in most products |
| 7-Hydroxymitragynine 7-OH | Mitragyna speciosa | Indole | Under action | DEA notice of intent, Jul 2026 | Yes | Was used as a primary active |
| Mitragynine pseudoindoxyl Pseudo | Mitragynine derivative | Indole | Under action | DEA notice of intent, Jul 2026 | Yes | Marketed as a 7-OH alternative |
| MGM-15 Oxonol | Semi-synthetic | Indole-derived | Under action | DEA notice of intent, Jul 2026 | Yes | Marketed as a 7-OH alternative |
| MGM-16 | Semi-synthetic | Indole-derived | Under action | DEA notice of intent, Jul 2026 | Yes | Named alongside MGM-15 |
| Kavalactones Kava | Piper methysticum | Lactone | Clear | Not scheduled | No | Relaxation base in kratom-free builds |
| Mesembrine Kanna | Sceletium tortuosum | Alkaloid | Clear | Not scheduled | No | Mood character in social builds |
| Caffeine | Multiple | Xanthine | Clear | Not scheduled | No | Stimulant; pairs with standalone 13-OH |
| Dehydrocorybulbine DHCB | Corydalis yanhusuo | Isoquinoline | Clear | Not scheduled | No | Another corydalis alkaloid |
The pattern in the source column
Filter to "under federal action" and look at what those four compounds have in common: every one is mitragynine or built on it. That is not coincidence. Once a chemical family draws regulatory attention, derivatives of that family inherit it — which is exactly what the salts-and-isomers principle in the Controlled Substances Act is designed to do.
Now filter to "currently clear." The corydalis alkaloids sit in a different structural family entirely, from a different plant, with no scheduling history for a derivative rule to attach to. The reasoning, with the primary sources, is here.
What the matrix does not tell you
Federal scheduling status is one body of law. It says nothing about food and supplement rules, labelling requirements, facility registration, local ordinances, or marketing claims — and that last one is where enforcement in adjacent categories has most often landed. A compound being unscheduled is the beginning of the analysis, not the end of it.
Working out what to build next?
The reformulation mapper turns three answers into a suggested route. Or tell us your situation directly and we will give you a straight assessment within one business day.