Reviewed August 2026 by the Corydalis Labs Technical Team. How we research and review.
The working range
25–40 mg
Per serving, in a blend. This is where the compound earns its place. 30 mg is the most common starting point and the one we would suggest for a first trial.
Under 25 mg
Contribution becomes difficult to distinguish from the rest of the formula. You will likely conclude it does nothing — not because it does nothing, but because you underdosed it.
100 mg+
Standalone territory. Requires pairing with caffeine or a botanical stimulant to produce a product worth selling.
The single most common mistake we see is a brand trialling at 10 or 15 milligrams to be cautious, concluding the compound is inert, and walking away. Start at 30. If you want to be conservative, be conservative on the mitragynine side instead.
What that means per kilogram
| Inclusion per serving | Servings per kilogram | Two-count blisters | Four-count blisters |
|---|---|---|---|
| 25 mg | 40,000 | 20,000 | 10,000 |
| 30 mg most common | 33,333 | 16,666 | 8,333 |
| 40 mg | 25,000 | 12,500 | 6,250 |
| 100 mg | 10,000 | 5,000 | 2,500 |
Run your own numbers on the yield calculator →
Format considerations
Tablets
Cross scoring lets a consumer take a quarter, half, or whole — genuinely useful in a category where people titrate to their own level. If you cross-score, dose the whole tablet for the experienced user and let the score handle everyone else. Our tablet minimum is 25,000 units. Format detail.
Liquid shots
Fill size changes how people use the product. A 15 ml shot reads as a single serve; a 60 ml bottle is often taken across two sittings, which means your per-serving inclusion and your per-bottle inclusion are different numbers. Decide which one your label is describing before you set the formula. Shot minimum is 15,000 units.
Running a bench trial
Three samples, one variable at a time:
- Control. Your current product, unchanged.
- Additive. Your current product plus 30 mg of 13-OH per serving, mitragynine unchanged. Shows what 13 adds.
- Substitutive. 30 mg of 13-OH with mitragynine reduced. Shows whether you can hit your target with a lighter alkaloid load — which is usually where the commercial case lands.
Use a panel rather than one evaluator, keep the flavour system identical across all three, and blind them if you can. Sensory work is noisy and the differences here are real but not enormous at first taste.
Working with other actives
Ingredients brands routinely combine with 13-OH, grouped by what they are being asked to do:
- Stimulants — caffeine, paraxanthine, theacrine, eria jarensis, alpha-GPC. Essential for standalone builds; optional in blends.
- Mood and relaxation — kanna, kava, GABA, L-theanine, 5-HTP, PEA, vitamin D.
- Comfort — L-phenylalanine, agmatine, THP, willow bark, valerian root.
- Absorption — piperine, which increases duration and perceived effect but noticeably degrades taste. Worth it in a tablet; think hard about it in a flavoured shot.
We formulate these routinely and will work through a build with you. Co-packing and formulation.
Common questions
In a blend, 25–40 mg per serving, with 30 mg the most common. Standalone use requires above 100 mg and should be paired with a stimulant. These are formulation figures for manufacturers, not consumption advice.
You can, but the contribution becomes hard to distinguish and most brands that trial low conclude the compound does nothing. If cost is the concern, the better lever is reducing mitragynine while holding 13-OH at 30 mg — which is usually where the economics work anyway.
Yes, and some brands do. Between 40 and 100 mg you are in a middle zone with diminishing return per milligram in a blend context. Above 100 mg you are effectively building a standalone product and should formulate it as one.
That is the most commonly reported benefit — formulators find they reach their target profile at a lower mitragynine inclusion. How much lower depends on your starting formula, which is why the three-sample bench trial is worth running properly.
Yes. Most brands start from one of three proven builds and adjust with our formulation team. You do not need a finished formula to start a conversation. Send us what you have.